Equipment
The Draper Group offers access to the Carterra LSA XT, a state-of-the-art high-throughput surface plasmon resonance (SPR) platform for the parallel characterisation of biomolecular interactions. This system enables rapid, label-free analysis of binding kinetics and epitope relationships, supporting research in vaccines, therapeutic antibodies, and small molecule discovery.
The facility is available to Oxford University researchers and external collaborators. We support across all stages of a project, including experimental design, assay selection, data acquisition, and analysis. Established workflows are available for antibody characterisation and T-cell receptor (TCR) affinity measurements, with additional applications developed in consultation.
Access to the platform is discussed on a project-by-project basis. For collaborative studies, the facility team can contribute to study design, data interpretation, and dissemination of results, with appropriate recognition in line with academic practice.
All projects begin with an initial discussion to define experimental objectives and scope.
For enquiries: draper_lsa@paediatrics.ox.ac.uk
Carterra LSA XT specifications
High-throughput SPR platform for parallel kinetic and epitope analysis.
- Measures up to 384 ligand spots simultaneously against a single analyte
- 1 Hz sampling rate, enhanced sensitivity; detects analytes down to ~500 Da
- Generates full kinetic datasets from a 384-spot array in ~8 hours per antigen
Low sample consumption
- <1 µg antibody per ligand for kinetic arrays
- <30 µg antibody for epitope binning
Established in-house assays
- Antibody kinetics
- Epitope binning
- TCR–pMHC affinity
- Peptide epitope mapping
Additional applications
- Small molecule screening
- DNA Encoded Library screening
- Quantification assays
More information: carterra-bio.com
