Simon Draper
Simon Draper is Professor of Vaccinology and Translational Medicine at the University of Oxford. His lab is based in the Department of Paediatrics, Department of Biochemistry and Kavli Institute for Nanoscience Discovery. The group’s clinical team are based at the University’s Centre for Clinical Vaccinology and Tropical Medicine.
The Draper Lab study vaccine-induced immunity, with a particular focus on antibody immunology and human malaria infection. A critical strength of the group is a strong dual focus on preclinical vaccine development in parallel with early-phase clinical vaccine testing and experimental medicine studies. In particular, the group’s research interests span: strategies for improved vaccine antigen identification; development of improved vaccine delivery strategies; assessment of quantitative antibody correlates of protective immunity; and assessment of human vaccine-induced antibody responses to guide immunogen design and to better understand protective mechanisms of immunity.
To date the group has undertaken 22 proof-of-concept Phase 1/2 clinical trials assessing novel vaccine delivery platforms and immunisation regimens; developing controlled human malaria infection (CHMI) models for Plasmodium falciparum and P. vivax; and testing novel blood-stage malaria vaccine antigens (PfRH5 for P. falciparum and PvDBP_RII for P. vivax). The PfRH5 clinical vaccine development programme now spans multiple partnerships across East and West Africa. The group has a strong track record of partnering with biotech and pharma, and participation in numerous collaborative programmes with academic and industrial partners, seeking to develop improved vaccines or antibody-based therapeutics.
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